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Research Advancements Focus on Biomarkers, Disease Management, COVID-19 and More

Jonathan Coulter credits his interest in prostate cancer to “the work of pioneers like Donald Coffey, who helped us understand the organization of massive amounts of DNA inside the tiny nucleus of a cell.”

Nephrology research


Despite the challenges posed by the COVID-19 pandemic, 2020 was an exciting year for researchers in the Johns Hopkins Division of Nephrology. Below are some of the high impact journal articles published by the team’s researchers in 2020. “The faculty continue to be the driving force in a series of discoveries contributing to groundbreaking progress in clinical care and mechanistic studies in patients with kidney disease,” says Chirag R. Parikh, Director of the Division of Nephrology at Johns Hopkins University School of Medicine.


Biomarkers of inflammation and repair in kidney disease progression.
Puthumana J, Thiessen-Philbrook H, Xu L, Coca SG, Garg AX, Himmelfarb J, Bhatraju PK, Ikizler TA, Siew E, Ware LB, Liu KD, Go AS, Kaufman JS, Kimmel PL, Chinchilli VM, Cantley L, Parikh CR. J Clin Invest. 2020 Dec 8:139927. doi: 10.1172/JCI139927. Online ahead of print. PMID: 33290282
Urine interleukin-9 and tumor necrosis factor-? for prognosis of human acute interstitial nephritis
Moledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Nephrol Dial Transplant. 2020 Oct 28:gfaa169. doi: 10.1093/ndt/gfaa169. Online ahead of print.
PMID: 33125471
A Systematic Review of Clinical Characteristics and Histologic Descriptions of Acute Tubular Injury.
Wen Y, Yang C, Menez SP, Rosenberg AZ, Parikh CR. Kidney Int Rep. 2020 Aug 31;5(11):1993-2001. doi: 10.1016/j.ekir.2020.08.026. eCollection 2020 Nov.
PMID: 33163720
Biomarkers of Immune Activation and Incident Kidney Failure With Replacement Therapy: Findings From the African American Study of Kidney Disease and Hypertension.
Chen TK, Estrella MM, Appel LJ, Coresh J, Luo S, Reiser J, Obeid W, Parikh CR, Grams ME.
Am J Kidney Dis. 2020 Dec 31:S0272-6386(20)31193-8. doi: 10.1053/j.ajkd.2020.11.014. Online ahead of print. PMID: 33388403
Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery.
Menez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Kidney Int. 2020 Jul 25:S0085-2538(20)30831-0. doi: 10.1016/j.kint.2020.06.037. Online ahead of print. PMID: 32721447
TCR + CD4 - CD8 - (double negative) T cells protect from cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.
Gong Jing, Sanjeev, Joshua Hsu, Bush Errol L, Arend Lois Noel J, Sadasivam Mohanraj, Lee Sul A, Kurzhagen Johanna T, Hamad Abdel Rahim A, Rabb Hamid. Am J Physiol Renal Physiol. 2020 Jun 1;318(6):F1500-F1512. doi: 10.1152/ajprenal.00033.2020. Epub 2020 Apr 13.

AKI: an increasingly recognized risk factor for CKD development and progression
J T Kurzhagen, Dellepiane S, Cantaluppi V, Rabb H. J Nephrol. 2020 Dec;33(6):1171-1187. doi: 10.1007/s40620-020-00793-2. Epub 2020 Jul 10.PMID: 32651850
Kidney diseases in the time of COVID-19: major challenges to patient care.
Hamid Rabb. J Clin Invest. 2020 Jun 1;130(6):2749-2751. doi: 10.1172/JCI138871. PMID: 32250968 PMCID: PMC7259985 (available on 2021-06-01)

CD4 + T Cell-Derived NGAL Modifies the Outcome of Ischemic Acute Kidney Injury.
Lee Sul A, Noel Sanjeev, Kurzhagen Johanna T, Sadasivam Mohanraj, Pierorazio Phillip M, Arend Lois J, Hamad Abdel R, Rabb Hamid. J Immunol. 2020 Feb 1;204(3):586-595. doi: 10.4049/jimmunol.1900677. Epub 2019 Dec 30. PMID: 31889023
The case for early identification and intervention of chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Shlipak MG, Tummalapalli SL, Boulware LE, Grams ME, Ix JH, Jha V, Kengne AP, Madero M, Mihaylova B, Tangri N, Cheung M, Jadoul M, Winkelmayer WC, Zoungas S; Conference Participants. Kidney Int. 2021 Jan;99(1):34-47. doi: 10.1016/j.kint.2020.10.012. Epub 2020 Oct 27. PMID: 33127436
Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Clase CM, Carrero JJ, Ellison DH, Grams ME, Hemmelgarn BR, Jardine MJ, Kovesdy CP, Kline GA, Lindner G, Obrador GT, Palmer BF, Cheung M, Wheeler DC, Winkelmayer WC, Pecoits-Filho R; Conference Participants. Kidney Int. 2020 Jan;97(1):42-61. doi: 10.1016/j.kint.2019.09.018. Epub 2019 Oct 10. PMID: 31706619
The FDA Metformin Label Change and Racial and Sex Disparities in Metformin Prescription among Patients with CKD.
Shin JI, Sang Y, Chang AR, Dunning SC, Coresh J, Inker LA, Selvin E, Ballew SH, Grams ME. J Am Soc Nephrol. 2020 Aug;31(8):1847-1858. doi: 10.1681/ASN.2019101119. Epub 2020 Jul 13.
PMID: 32660971
Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis : An Individual Participant-Based Meta-analysis.
Sumida K, Nadkarni GN, Grams ME, Sang Y, Ballew SH, Coresh J, Matsushita K, Surapaneni A, Brunskill N, Chadban SJ, Chang AR, Cirillo M, Daratha KB, Gansevoort RT, Garg AX, Iacoviello L, Kayama T, Konta T, Kovesdy CP, Lash J, Lee BJ, Major RW, Metzger M, Miura K, Naimark DMJ, Nelson RG, Sawhney S, Stempniewicz N, Tang M, Townsend RR, Traynor JP, Valdivielso JM, Wetzels J, Polkinghorne KR, Heerspink HJL; Chronic Kidney Disease Prognosis Consortium. Ann Intern Med. 2020 Sep 15;173(6):426-435. doi: 10.7326/M20-0529. Epub 2020 Jul 14.
PMID: 32658569
Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate.
Qiao Y, Shin JI, Chen TK, Inker LA, Coresh J, Alexander GC, Jackson JW, Chang AR, Grams ME. JAMA Intern Med. 2020 May 1;180(5):718-726. doi: 10.1001/jamainternmed.2020.0193.PMID: 32150237
National Trends in the Prevalence of Chronic Kidney Disease Among Racial/Ethnic and Socioeconomic Status Groups, 1988-2016.
Vart Priya, Powe Neil R, McCulloch Charles E, Saran Rajiv, Gillespie,Brenda W Saydah Sharon, Crews Deidra C, Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team. JAMA Netw Open. 2020 Jul 1;3(7):e207932. doi: 10.1001/jamanetworkopen.2020.7932.
PMID: 32672828
COVID-19, Racism, and Racial Disparities in Kidney Disease: Galvanizing the Kidney Community Response.
Crews Deidra C, Purnell Tanjala S.  J Am Soc Nephrol. 2020 Aug;31(8):1-3. doi: 10.1681/ASN.2020060809. Epub 2020 Jul 13. PMID: 32660968
Distal convoluted tubule sexual dimorphism revealed by advanced 3D imaging.
Tahaei E, Coleman R, Saritas T, Ellison DH, Welling PA.
Am J Physiol Renal Physiol. 2020 Nov 1;319(5):F754-F764. doi: 10.1152/ajprenal.00441.2020. Epub 2020 Sep 14. PMID: 32924546
Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Louis-Dit-Picard H, Kouranti I, Rafael C, Loisel-Ferreira I, Chavez-Canales M, Abdel-Khalek W, Argaiz ER, Baron S, Vacle S, Migeon T, Coleman R, Do Cruzeiro M, Hureaux M, Thurairajasingam N, Decramer S, Girerd X, O'Shaugnessy K, Mulatero P, Roussey G, Tack I, Unwin R, Vargas-Poussou R, Staub O, Grimm R, Welling PA, Gamba G, Clauser E, Hadchouel J, Jeunemaitre X. J Clin Invest. 2020 Dec 1;130(12):6379-6394. doi: 10.1172/JCI94171. PMID: 32790646
GDNF drives rapid tubule morphogenesis in a novel 3D in vitro model for ADPKD.
Dixon EE, Maxim DS, Halperin Kuhns VL, Lane-Harris AC, Outeda P, Ewald AJ, Watnick TJ, Welling PA, Woodward OM. J Cell Sci. 2020 Jul 16;133(14):jcs249557. doi: 10.1242/jcs.249557.
PMID: 32513820
Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology.
Batlle D, Soler MJ, Sparks MA, Hiremath S, South AM, Welling PA, Swaminathan S; COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group. J Am Soc Nephrol. 2020 Jul;31(7):1380-1383. doi: 10.1681/ASN.2020040419. Epub 2020 May 4.
PMID: 32366514 Review.
NBCe1-A is required for the renal ammonia and K+ response to hypokalemia.
Lee HW, Harris AN, Romero MF, Welling PA, Wingo CS, Verlander JW, Weiner ID. Am J Physiol Renal Physiol. 2020 Feb 1;318(2):F402-F421. doi: 10.1152/ajprenal.00481.2019. Epub 2019 Dec 16. PMID: 31841393

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