Chapters Transcript Video Apolipoprotein L1 (APOL1) in African Americans SLE Michelle Petri who is the Director of The Johns Hopkins Lupus Center discusses lupus outcomes in African Americans. Yeah. Mhm. There's absolutely no doubt that african american lupus is worse. This is particularly true in two areas development of end stage kidney disease and total organ damage. It has been known for some time from large genome wide association studies and other studies that a gene called a paul L. In African americans is a major contributor to end stage kidney disease. This gene was identified in the general population of african americans as a cause of kidney failure In Lupus. It's like two shots on the kidneys. If the person is african american, we already know their lupus nephritis is going to be worse. And if they also have this April one gene, we know that they're much more likely to have end stage kidney disease. A Paul one is a gene that contributes to kidney scarring. We don't have any treatment for it yet. So all the patients in this study, we're being maximally treated for lupus nephritis and yet went on to kidney film Someday. We will have treatments for a palm one just not yet. Our study confirms the role of April one in kidney failure in african americans, but it did not show any association with a predniSONE related hip damage called a vascular necrosis. This is in contrast to an earlier study from Ny that suggested there was such an association, we had a larger number of patients and did not even find a trend towards a vascular necrosis. So we think that the importance of April one is going to be limited to kidney failure in african americans with lupus. Mhm. Yeah Created by Related Presenters Michelle Petri, MD, MPH Director, Johns Hopkins Lupus Center Professor of Medicine View full profile