Pediatric Orthopaedics Articles & Documents

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Quick Intervention Guide for Sudden Hearing Loss

Timely recognition of sudden sensorineural hearing loss by the initial evaluating physician affects the availability of treatment options as well as the treatment success rates.

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Improving Management of Liver Disease in Children

Over the past several years, clinicians have made use of a free genetic test to help properly diagnose infants presenting with signs of liver disease.

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ATA2023 Conference & Expo

ATA2023 Conference & Expo March 4-6, 2023 Henry B. Gonzalez Convention Center San Antonio, Texas

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Calculating Thoracic Outlet Surgery Success

New research by Johns Hopkins vascular surgeon predicts which patients will have positive surgical outcomes.

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Johns Hopkins Pediatric Rehabilitation Brings Size, Synergies to Patient Care

The Pediatric Rehabilitation division within the Department of Physical Medicine and Rehabilitation at Johns Hopkins Medicine is one of the largest in the nation, with 11 pediatric physiatrists plus associated specialists at four locations.

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Remote Monitoring for Congenital Heart Disease

As a pediatric heart surgeon and research scientist, Danielle Gottlieb Sen has long felt the need for a simple, noninvasive monitoring device that babies with congenital heart disease could wear — the way their parents might wear a smartwatch ...

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Meet Our New Pediatric Gastroenterologists

Meet Our New Pediatric Gastroenterologists

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Multidisciplinary Care for Rare Ovarian Cancer

The team at Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital drew on its vast knowledge and experience to treat a patient with granulosa cell tumor.

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New Pediatric Epileptologist Joins Johns Hopkins

Pediatric epileptologist Babitha Haridas specializes in the diagnosis and treatment of children with epilepsy, with a focus on those who have refractory epilepsy. Dr. Haridas seeks alternate modalities of treatment, including ketogenic ...

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Adult Inpatient Brexanolone Service Addresses Postpartum Depression

A new service at Johns Hopkins offers a novel method to treat postpartum depression: administering a rapidly-acting intravenous medication in inpatient psychiatry units, where patients can benefit from related services.

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Clinicians’ Review of Scientific Studies Underscores Links Between Climate Change and Nose and Sinus Conditions

In a new review article, Johns Hopkins Medicine experts and collaborators across the U.S. emphasize that climate change — particularly global warming — is contributing to an increase in the rates and to greater severity of nasal and sinus ...

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Gastroenterologist Develops Gel to Stop Bleeding After Precancerous Polyp Removal

Venkata Akshintala leads a team of pharmacologists, biomedical engineers and mechanical engineers to create a gel that uses epinephrine nanoparticles to stop bleeding following a procedure.

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Pediatric Nephrologist Jeffery Fadrowski Elected to International Council

Jeffrey Fadrowski, a pediatric nephrologist and an associate professor of pediatrics at Johns Hopkins, has been elected to the International Pediatric Nephrology Association (IPNA) council.

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Unlocking the Promise of Nanomaterials

It used to be that if you received a diagnosis of glaucoma, chances were good that you would eventually lose vision to some degree. That began to change with the development of drugs that lower intraocular pressure, elevated levels of which can drive glaucoma.

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Improving Care for Advanced Obstetric Surgery Patients

Jason Vaught, Torre Halscott and colleagues at Johns Hopkins’ Advanced Obstetric Surgery Center provide a breadth of expertise to treat patients who need extraordinary care.

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Can Total Joint Replacement Complication Rates Be Reduced?

Research by Johns Hopkins orthopaedic surgeon Savyasachi Thakkar suggests opportunities for safety and outcome improvements based on timing of multiple procedures.

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Innovations in Adult Congenital Heart Disease

Cardiologist Stacy Fisher helped to create a 3D model of a congenital heart to help guide formation and implant of a catheter-based stent to avoid open heart surgery for her patient who had a collateral vessel stealing coronary blood and ...

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Nanofiber-Hydrogel Loaded with Stem Cells Shows Success Treating Severe Complication of Crohn’s Disease

In a new study using a rat model of Crohn’s disease, a biodegradable hydrogel composite loaded with stem cells, developed by Johns Hopkins Medicine researchers, in a collaborative effort with the Whiting School of Engineering, has shown ...

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Minimally Invasive Spine Surgeries Offer Better Outcomes, Faster Recovery

Neurosurgeon David Lin discusses the benefits of artificial cervical disk replacement and microdiscectomy.

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For Stage 2 Colon Cancers, Circulating Tumor DNA May Reduce Unnecessary Chemotherapy

Study led by Johns Hopkins and Australian collaborators could change standard of care.

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Identifying the Seizure Onset Zone Through Single-Pulse Electrical Stimulation

New study by Johns Hopkins researchers could significantly shorten monitoring time before epilepsy surgery and improve outcomes

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Should We Burn Barrett’s Esophagus? Or Should We Freeze It?

Clinical trials led by Johns Hopkins endoscopy specialists investigate cryotherapy approach to treat Barrett’s esophagus.

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Improving Pancreatic Cancer Survival Through Surveillance

Johns Hopkins-led study shows that for patients at high risk of developing disease, annual screening caught most pancreatic cancers in early, treatable stages.

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Entrepreneurship Certificate Program Targets Prevention and Treatment of Substance Use Disorders

A $1.6M grant will fund efforts to train basic scientists in the development and commercialization of products to prevent and treat substance use disorders.

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New Research into Treatment for Bipolar Depression

Johns Hopkins psychiatrists study whether an unconventional transcranial magnetic stimulation (TMS) yields more rapid improvements in patients.

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New Research Advances the Field of Head and Neck Endocrine Surgery

Johns Hopkins physician-researchers are leading studies on scarless thyroglossal duct removals and parathyroidectomies, fighting cancer by leveraging metabolism, intraoperative monitoring to protect the recurrent laryngeal nerve, and more.

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Johns Hopkins Gastroenterologist First in U.S. to Perform POEM+F—Recently Developed Approach for Achalasia and Acid Reflux

In 2012, Dr. Mouen Khashab, professor in the Division of Gastroenterology & Hepatology, pioneered peroral endoscopic myotomy (POEM) to treat esophageal achalasia – a disorder of the esophagus that makes swallowing difficult.

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New Studies Suggest Social Isolation Is a Risk Factor for Dementia in Older Adults, Point to Ways to Reduce Risk

In two studies using nationally representative data from the National Health and Aging Trends Study gathered on thousands of Americans, researchers from the Johns Hopkins University School of Medicine and Bloomberg School of Public Health ...

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The Nose Knows: Study Suggests It May Be Wise to Screen For Smell Loss to Predict Frailty and Unhealthy Aging

In a study using data from nearly 1,200 older adults, Johns Hopkins Medicine researchers have added to a growing body of evidence that loss of the sense of smell is a predictive marker for an increased risk of frailty as people age.

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Forty Years of Neurocritical Care

One of the world’s first neurosciences critical care units opened at Johns Hopkins in 1982, innovating patient care and inspiring hundreds of similar efforts globally.

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Research and Clinical Advances in Laryngology at Johns Hopkins

Physician-researchers in the Division of Laryngology advance clinical research and practice — leading studies on retrograde cricopharyngeal dysfunction, gender-affirming voice care and more.

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Hope for Patients Grappling with Pancreatic Pain

Psychiatrist and pain specialist Traci Speed works with colleagues at the Johns Hopkins Pancreatitis Pain Program to address each patient’s struggles with pain and mental health.

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School-Based Mental Health Program Aims to Help Kids Become Their Best Selves

Hal Kronsberg, program director for the Johns Hopkins Child and Adolescent Psychiatry Fellowship Program, shares observations about his and his team’s approach to assist children who grapple with mental illness.

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Research Focuses on Improving Care for People with Dementia

Adults with dementia are sometimes thought to be homogenous and presumed to use a lot of health care services, especially later in life, says geriatrician Stephanie Nothelle. But two recent studies Nothelle directed suggest that’s not the case.

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A New Approach to Preserving Spine Mobility in Middle-aged Adults

Unique expertise, multidisciplinary treatment and new surgical techniques lead to better outcomes for adults with spinal deformities.

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Johns Hopkins Research Suggests Ways to Improve the Medicare Annual Wellness Visit

A new study from Johns Hopkins researchers offers caution about the limitations of the Medicare Annual Wellness Visit, finding that up to 25% of older adults at risk for falls still were prescribed a medication that is considered high risk for that condition.

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Program That Trains Community Health Workers to Deliver Hearing Care Shows Success Among Low-Income Older Adults

A first-in-kind program that trains trusted older adult community health workers to fit and deliver low-cost hearing technology to peers with hearing loss significantly improved communication function among participants, according to the ...

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Serving the LGBTQ Community at the Johns Hopkins Fertility Center

Fertility specialists offer full range of options for same-sex and transgender couples, as well as those who choose to be single parents.

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A Multidisciplinary Approach to Hypertrophic Cardiomyopathy: The Right Treatment for Each Patient

As the new surgical director of structural heart disease at the Johns Hopkins Heart and Vascular Institute, Michael Robich is building a program to streamline the referral and admission process for physicians from outside of Johns Hopkins ...

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Precision Medicine: Genetics and Clinical Outcomes in Advanced Prostate Cancer

No two men with prostate cancer have exactly the same disease. Instead, each has distinct genomic and molecular changes that make the cancer more or less likely to respond to a particular treatment – and scientists still have much to learn ...

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Newly Discovered Mutation on HOXB13 is Linked to More Aggressive Cancer in Black Men

Three decades ago, Brady investigators William Isaacs, Ph.D., the William Thomas Gerrard, Mario Anthony Duhon, and Jennifer and John Chalsty Professor of Urology, and Patrick Walsh, M.D., characterized hereditary prostate cancer, and in ...

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Recent Brady Honors & Awards

Burnett was recognized for his “groundbreaking advances in male sexual health, as well as advocacy, diversity and humanitarian contributions.”

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Schaufeld Program Celebrates First Year

Last year in Discovery, we introduced an exciting new initiative, the Schaufeld Program for Prostate Cancer in Black Men, which addresses a critical issue: Black men are more likely to develop aggressive prostate cancer, and to die of it, than other men.

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Read About the Research You Have Helped Make Possible.

How important is seed money? Priceless! Many of the scientists featured in this issue of Discovery jump-started their research careers with awards from the Patrick C. Walsh Prostate Cancer Research Fund.

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GSTP1: Could This Gene Be Linked to Cancer Death in Black Men?

Black men in the U.S. are nearly twice as likely to die of prostate cancer than white men. What accounts for this terrible statistic?

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Kidney Cancer and Brain Metastases

Most people with kidney cancer don’t have metastasis to the brain. But 15 percent of patients with advanced kidney cancer do, says urologic oncologist Nirmish Singla, M.D., M.S.C.S., Director of the Kidney Cancer Program.

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Prostate Cancer in Transgender Patients

Although it is quite rare, aggressive prostate cancer can occur in transgender patients on long-term hormone therapy.

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Kidney Cancer Program: World-class Care and Research

The Kidney Cancer Program (KCP), jointly led by urologist Nirmish Singla and oncologist Yasser Ged, was established with the goal of offering world-class, multidisciplinary clinical care and cutting-edge collaborative research “to continuously ...

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Turning Back the Clock on Treatment-Resistant Prostate Cancer

If this hypothesis proves true, an LSD1-blocking agent could allow ADT and AR-blocking drugs to work again in men with mCRPC.

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Race, Ethnicity and Clinical Trials

There are significant differences in cancer – even the same type of cancer – among people of different racial and ethnic backgrounds.

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Therapy Resistance in Cancer: Learning from Bacteria

Why is metastatic prostate cancer so hard to kill? The short answer is that nobody knows.

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Taking a Deeper Look at Trigeminal Neuralgia

Risheng Xu’s research aims to unravel the nature of the puzzling condition — from bench to bedside.

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Johns Hopkins Adds to Colorectal Treatment Team in the National Capital Region

Ada Graham, a fellowship-trained colorectal surgeon, has joined Johns Hopkins Medicine in the National Capital Region.

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Anatomic Parameters: Direct Intralaminar Screw Repair of Spondylolysis

To determine parameters for ideal intralaminar screw trajectory and the feasibility of screw placement at L3, L4, and L5 laminae for pars defect fixation.

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Clinical Results and Functional Outcomes After Direct Intralaminar Screw Repair of Spondylolysis

Our objective was to analyze clinical and functional results of patients with spondylolysis treated via direct intralaminar screw fixation and autograft, a minimally invasive and motion-preserving surgery.

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Shunning the Shunt in Hydrocephalus?

Since they first met a decade ago, pediatric neurosurgeon Dody Robinson and neuroscientist Lauren Jantzie have been collaborating on research to better understand the disease processes that cause brain damage in infants.

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Intralaminar Screw Fixation of Spondylolysis

Spondylolysis, defined as injury to the pars interarticularis, is the most common identifiable cause of back pain in children.

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Life-saving Options for Patients with Complex Heartbeat Irregularities

Patients with complex heartbeat irregularities can now get Johns Hopkins care in the National Capital Region.

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Managing a Tumor Thrombus in Kidney Cancer

Managing Kidney Cancer “Some patients with renal cell carcinoma (RCC) display a unique pattern of local invasion known as tumor thrombus: the cancer invades the major vein that drains the kidneys and can potentially climb up to the heart,” ...

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Neoadjuvant Therapy and High-Risk Localized Prostate Cancer

The next step is a multicenter randomized, placebo-controlled trial of Enoblituzumab.

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Neoadjuvant Chemotherapy and Surgery for MIBC: What’s a Successful Response?

Neoadjuvant chemotherapy is the standard of care for cisplatin-eligible patients with MIBC who undergo radical cystectomy (removal of the bladder).

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Exercise, Immunotherapy, and Metastatic Kidney Cancer

Obesity is a known risk factor for renal cell carcinoma, and patients with renal cell carcinoma who have muscle mass loss have a less favorable prognosis,” says medical oncologist Yasser Ged, M.B.B.S.

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First-of-Its-Kind Trial to Test Immune Therapy for Post-COVID-19 POTS

It didn’t take long after the coronavirus pandemic began for Johns Hopkins experts to launch a clinic for patients experiencing postural orthostatic tachycardia syndrome (POTS) following a SARS-CoV-2 infection.

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Finding Metastatic Prostate Cancer that Doesn’t Make PSMA

Two huge advances have dramatically changed the diagnosis and treatment of metastatic prostate cancer, and both of these involve prostate-specific membrane antigen (PSMA), a molecule that sits on the surface of prostate cancer cells.

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Embryonic Genes Reactivated in Advanced Prostate Cancer

Embryonic genes are supposed to fulfill their mission before we are ever born and then shut themselves off. But somehow, metastatic castration-resistant prostate cancer (mCRPC) manages to reactivate these genes from our period of earliest development.

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DNA Damage-Repair Gene Mutations and Neoadjuvant Chemotherapy in MIBC

Mutations in DNA damage-repair (DDR) genes – the best-known of these genes are BRCA1/2, linked to breast, ovarian, colon and prostate cancer – make it more likely that someone will get cancer, and get a more aggressive form of it. But ...

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After 45 Years at the Brady, John Isaacs Retires

In 2022, after a 45-year career at Hopkins, John T. Isaacs, Ph.D., Professor of Oncology and Urology, retired. John is a pioneer in the translation of basic science theory into clinical trials for lethal prostate cancer.

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A Novel Study for Patients with Small Cell Bladder Cancer

Hoffman-Censits and Hopkins colleagues are testing the combination of the FDA-approved checkpoint inhibitor, Atezolizumab, and standard chemotherapy in patients with newly diagnosed, localized SCBC.

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Gleason 3+3=6 is Not “Not Cancer”

Grade Group 1 cancer has some of the same behaviors as higher grade cancer. It’s invasive, and it can appear in perineural invasion and extra prostatic extension

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For Prostate Cancer Patients with Mismatch Repair Deficiency, Immunotherapy Alone?

All patients in the study will receive nivolumab, a form of immunotherapy, without the addition of ADT

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Computer Modeling Improves Outcomes in Reverse Total Shoulder Replacement

Johns Hopkins orthopaedic surgeons perform reverse total shoulder arthroplasty for an assortment of complex shoulder ailments, with good outcomes.

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Pranita Tamma Honored for Antimicrobial Resistance Research

Pranita Tamma, M.D., M.P.H., pediatric infectious diseases specialist and researcher and associate professor of pediatrics, has been awarded the seventh annual Gale and Ira Drukier Prize in Children’s Health Research from Weill Cornell Medicine.

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Averting Crisis During the Infant Formula Shortage

By tapping into the power of data and taking a team-driven approach, leaders at Johns Hopkins Children’s Center have provided critical intervention to keep fragile patients safe.

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New Procedure for Gastroesophageal Reflux Disease May Yield Improved Outcomes for Certain Patients

Via collaboration among surgeons and gastroenterologists, Johns Hopkins patients receiving combined transoral incisionless fundoplication, or cTIF, could see better results compared with traditional treatments.

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Johns Hopkins Researchers Make New Discoveries in Neurology and Neurosurgery

Physicians and scientists within the institution bolster understanding in both fields, with the aim of enhancing patient care.

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Johns Hopkins Researchers Generate Lab-Grown Human Tissue Model for Food Tube Cancer

Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional “organoid” model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal ...

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New Tools Map Seizures, Improve Epilepsy Treatment

Two new models could solve a problem that’s long frustrated millions of people with epilepsy and the doctors who treat them: how to find precisely where seizures originate to treat exactly that part of the brain.

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Is There a PSMA for Kidney Cancer?

A potential candidate for radiopharmaceutical therapy: GPNMB

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Gut Bugs and Treatment Response in Metastatic Prostate Cancer

Even as medications work to suppress levels of male hormones, certain bacteria in the gut start their own hormone factory.

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Low-Intensity Electrostimulation May Improve Erectile Recovery

Low-intensity electrostimulation has been shown to enhance peripheral nerve regeneration. Can it stimulate regeneration in the nerves that control erection, and improve recovery of erectile function after prostatectomy?

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Micro-Ultrasound: A New Approach to Prostate Biopsy

This is a new tool being studied and used by Gerald Andriole Jr., M.D., Professor and Director of Urology in the National Capital Region of the Brady Urological Institute.

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Acceptance of Comprehensive Opioid Treatment Programs, Emphasis on Comprehensive – Notes from AATOD Conference

The 2022 American Association for the Treatment of Opioid Dependence, Inc. (AATOD) Conference, the largest gathering of the opioid treatment field and the conference oriented specifically toward treatment in opioid treatment programs (OTPs), ...

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Addressing Disparities in Access to Children’s Mental Health Care – Notes from AACAP Annual Meeting

Andrea Young, Ph.D., assistant professor in the Johns Hopkins Department of Psychiatry and Behavioral Sciences and assistant dean for graduate biomedical education and graduate student diversity at the Johns Hopkins University School of ...

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Johns Hopkins Researchers Find Close Temporal Relationship Between Cancer and Scleroderma Onset among Patients with Anti-RNA pol3

An interview with Ami Shah, co-director of the Johns Hopkins Scleroderma Center

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Evolving Approaches for Gastric Cancer

Researchers in the Johns Hopkins Department of Surgery are conducting a first-of-its-kind study with the aim of converting patients who typically are not considered candidates for hyperthermic intraperitoneal chemotherapy surgery into ...

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Johns Hopkins Center for Fetal Therapy Delivers Highest Level of Care, Says Network

The North American Fetal Therapy Network names the center’s team among the most adept at comprehensive and complex treatments.

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Research and Practice Advances in Pediatric Otolaryngology–Head and Neck Surgery

Johns Hopkins researchers are studying otolaryngology-related surgery for patients with achondroplasia, how COVID-19 affects infant hearing screening and more.

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Changing Lives Through Cardiac Ablation

Zeshan Ahmad, Johns Hopkins’ director of complex cardiac ablations for the National Capital Region, is among few in the mid-Atlantic region to perform certain procedures that improve atrial fibrillation and other arrhythmias.

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Living Testament

Transplant recipient Sara Kathryn Smith — the new medical director of pediatric liver transplantation — has a hard-won perspective on what it means to live with advanced liver disease.

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Proton Therapy Case Studies – Gynecologic Cancers

Proton beam radiation therapy is an FDA-approved treatment modality. Proton beam therapy directs a beam of protons (positively charged subatomic particles) at the radiation target, where they deposit the bulk of their energy in the last ...

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A New Foundation for Precision Rehabilitation

Johns Hopkins is among the first in the U.S. to develop technologies that collect and store data regarding multiple facets of physical function. The aim: to spur novel research and advance rehabilitation.

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Johns Hopkins Adds Surgical Oncology to National Capital Region

Ivey has joined Johns Hopkins as the first surgical oncologist to be based at the Johns Hopkins Kimmel Cancer Center in the National Capital Region. He treats patients at Sibley Memorial Hospital and Suburban Hospital.

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Johns Hopkins Study Examines Potential Link Between Household Air Pollution from Biomass Stoves and Low Birthweight in Newborns

According to the Health Effects Institute, more than three billion people around the world cook on open fires using solid fuels — or biomass — such as wood, dung, charcoal and agricultural waste. These types of stoves are not commonly ...

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Educational Surgical Seminar Series at Green Spring Station

Johns Hopkins orthopaedic surgeons practicing at Green Spring Station invite you to attend a series of talks that highlight interesting case presentations and latest developments in the field of orthopaedic surgery. Light refreshments will be served.

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Family Caregivers Share Both Positive And Challenging Experiences In New Study

An old adage goes something like this: “Growing old is not for the faint of heart.” Perhaps there’s something else about the aging human condition at parity with this wisdom: caregiving is both challenging and rewarding.

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Embracing a Minimally Invasive Philosophy in Foot and Ankle Surgery

A minimally invasive approach is a viable option in unique and complex foot and ankle conditions, and can work where other approaches have failed, finds Amiethab Aiyer, the division chief of foot and ankle surgery.

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Meet Our New Neurologists

Meet Our New Neurologists

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Significant Boost in Rates of Type 2 Diabetes Among Children During COVID-19 Pandemic

In a multi-site study of medical records, researchers at Johns Hopkins Children’s Center and across the United States say they have documented a steep rise in type 2 diabetes among children during the COVID-19 pandemic.

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Pulse Ox: Vital Tech with a Fatal Flaw

In the early days of the COVID-19 pandemic, Ashraf Fawzy remembers one patient who arrived in the intensive care unit of The Johns Hopkins Hospital, a Black woman with asthma.

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Keeping Reproductive Health, Research and Care at the Forefront

Leader of the Johns Hopkins Department of Gynecology and Obstetrics, Andrew Satin, shares his thoughts regarding the U.S. Supreme Court’s recent decision on Dobbs v. Jackson, as well as his reflections on current research in the department and more.