Zachary Newton, M.D., a fellow in the Division of Pediatric Nephrology at the Johns Hopkins University School of Medicine, will discuss his team’s findings indicating that insufficient levels of vitamin D are associated with dyslipidemia in children with CKD.
Hi I'm Zach Newton, 2nd year pediatric nephrology fellow at Johns Hopkins. The title of my abstract is 25 hydroxy vitamin d. deficiency and risk of diesel epidemiology and Children with chronic kidney disease. Vitamin D. Plays an important role in helping the body build and maintain bone. However, vitamin D. Deficiency is quite common in the U. S. And worldwide and can lead to weak bones as well as other health problems in adults. Vitamin D deficiency has also been identified as a risk factor for Disl epidemiology. People with this liberty miA have inappropriate levels of lipids, either too much bad cholesterol or too little good cholesterol and this can lead to build up of cholesterol plaque and blood vessels and if there's too much build up the blood vessel can become blocked, leading to heart attack, stroke or blood clot. Due to these risks. We looked at the association between vitamin D. And D. Slip anemia in Children, which is not Venezuela explored. We focus specifically on Children with chronic kidney disease who have been shown to have high prevalence of both vitamin D. Deficiency and anemia. We performed a cross sectional analysis using longitudinal data from just under 600 Children in the chronic kidney disease. In Children study, which is a multi center prospective cohort study of Children with chronic kidney disease. We compared vitamin D levels. At one study, visit with cholesterol or lipid levels at the following study visit And we had a total of 1,012 of these paired measurements, we found that Children with vitamin D deficiency had a significantly higher prevalence of three Clinically determined definitions of dis lipid E. Mia. I. Triglycerides, high non HDL cholesterol and low HDL cholesterol when compared with those with sufficient vitamin D. After taking into account other possibly confounding factors including the amount of protein in the urine, kidney filtering ability underlying cause of chronic kidney disease and body mass index or B. M. I. Vitamin D. Sufficiency remained associated with 38% lower odds of high non HDL cholesterol. Non HDL is important for clinical management of cardiovascular disease risk because it's less likely to be impacted by fasting status when checking cholesterol levels and is often what the recommendations tell us we should target. These findings can help identify patients at higher risk of this lipid E. MiA based on the vitamin D. Sufficiency. The study findings also warrant further investigation into whether providing supplemental vitamin D. To these Children may prevent or delay progression of disability. MiA. And finally I want to thank my co authors, jubilee Kumar, joseph Flynn Derek King and my mentor MEREDITH Atkinson. Thanks so much