Regulation of TDP-43 Nucleocytoplasmic Shuttling and Therapeutic Targeting

Johns Hopkins neurologist Lindsey Hayes discusses her research related to amyotrophic lateral sclerosis (ALS). She studies the basic cell biology that regulates transactive response DNA binding protein 43 (TDP-43), an essential RNA binding protein found in all types of cells in the body. TDP-43 becomes disrupted in patients with ALS and related neurodegenerative disorders. TDP-43’s reliance on binding to RNA may have important implications for understanding why it is disrupted in disease and may suggest strategies for designing therapies to prevent TDP-43 pathologies.

Created by

Johns Hopkins Medicine

Related Presenters

Lindsey Hayes, M.D., Ph.D.

Lindsey Hayes, M.D., Ph.D.

Assistant Professor of Neurology

Dr. Hayes specializes in amyotrophic lateral sclerosis (ALS) and related neuromuscular disorders and conducts translational research on ALS/FTD pathogenesis and treatment. She received her M.D. and Ph.D. from Emory University in Atlanta. ...

View full profile