Clinical Research Advancements Articles

Articles

New Center to Explore the Influence of Sex and Gender on Health Care

Gender-specific medicine considers how human biology differs between men and women and how the diagnosis and treatment of diseases may differ regarding both biological sex and gender-specific lived experience.

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Inflammatory Biomarker Associated with Mitochondrial Decline Further Linked to Frailty

Researchers at the Johns Hopkins University School of Medicine have developed a mouse model that successfully mimics the development of frailty as mammals — likely including people — get older.

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New Findings Show Mitochondrial DNA Fragments in Blood as Important Biomarkers for Aging and Inflammation

In an eight-year study of more than 600 community-dwelling older adults, Johns Hopkins Medicine researchers say they have further linked levels of cell-free DNA (DNA fragments resulting from cell death) circulating in the blood to chronic ...

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New Studies Suggest Social Isolation Is a Risk Factor for Dementia in Older Adults, Point to Ways to Reduce Risk

In two studies using nationally representative data from the National Health and Aging Trends Study gathered on thousands of Americans, researchers from the Johns Hopkins University School of Medicine and Bloomberg School of Public Health ...

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Research Focuses on Improving Care for People with Dementia

Adults with dementia are sometimes thought to be homogenous and presumed to use a lot of health care services, especially later in life, says geriatrician Stephanie Nothelle. But two recent studies Nothelle directed suggest that’s not the case.

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Johns Hopkins Research Suggests Ways to Improve the Medicare Annual Wellness Visit

A new study from Johns Hopkins researchers offers caution about the limitations of the Medicare Annual Wellness Visit, finding that up to 25% of older adults at risk for falls still were prescribed a medication that is considered high risk for that condition.

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Johns Hopkins Researchers Find Close Temporal Relationship Between Cancer and Scleroderma Onset among Patients with Anti-RNA pol3

An interview with Ami Shah, co-director of the Johns Hopkins Scleroderma Center

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Family Caregivers Share Both Positive And Challenging Experiences In New Study

An old adage goes something like this: “Growing old is not for the faint of heart.” Perhaps there’s something else about the aging human condition at parity with this wisdom: caregiving is both challenging and rewarding.

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Pulse Ox: Vital Tech with a Fatal Flaw

In the early days of the COVID-19 pandemic, Ashraf Fawzy remembers one patient who arrived in the intensive care unit of The Johns Hopkins Hospital, a Black woman with asthma.

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Blood Levels of ‘Free Range’ DNA May Signal Early Detection of Dementia and Frailty

In a long-term prospective study of more than 600 older participants, Johns Hopkins Medicine researchers say they have evidence that higher levels of cell-free DNA circulating in the blood may signal increased risk of chronic inflammation ...

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Understanding Patient Preferences for Deprescribing Medications

Geriatricians routinely see older adults who are prescribed an overload of medicines that may not benefit them or be aligned with their goals —and that often cause harm including falls, cognitive impairment, hospitalization and death. ...

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Sjögren’s Disease: Making the Correct Diagnosis

An Interview with Alan Baer, founding Director of the Jerome L. Greene Sjögren’s Center at Johns Hopkins.

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Advances in Precision Medicine for Scleroderma and Myositis

New Johns Hopkins research aims to better predict trajectories of disease and how patients will respond to treatments.

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Research Advancements Focus on Biomarkers, Disease Management, COVID-19 and More

Despite the challenges posed by the COVID-19 pandemic, 2020 was an exciting year for researchers in the Johns Hopkins Division of Nephrology. Here are some of the high impact journal articles published by the team’s researchers in 2020.

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Inclusion Body Myositis: Learning from Musician Peter Frampton

Frampton’s finger dexterity was not at all what his doctor, rheumatologist Lisa Christopher-Stine, M.D., Director of the Johns Hopkins Myositis Center, expected to find; then again, neither was Frampton himself.

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PTLD: Recent Advancements in Long-Haul Lyme Disease Research

Some people get bitten by a deer tick that’s infected with Borrelia burgdorferi, develop a rash, are diagnosed with Lyme disease, take antibiotics, feel better, and get their life back to normal. Others aren’t so lucky. Diagnosed just ...

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Racial/Ethnic Disparities in Care for Patients with Failing Kidneys Unchanged for Decade

A new study by Johns Hopkins Medicine, the Johns Hopkins Bloomberg School of Public Health, the Harvard Medical School and the Duke University School of Medicine shows that racial and ethnic disparities in the availability and quality ...

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For Blacks with Respiratory Ills, Individual and Neighborhood Poverty Yield Worse Outcomes

Socioeconomic status — for both individuals and the neighborhoods in which they live — can negatively impact the health outcomes for Blacks with chronic obstructive pulmonary disease and other respiratory illnesses.

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Molecularly Targeted Therapies for Salivary Gland Cancer

Experts at the Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital use highly specialized hormone therapy to target salivary gland tumors based on genetic characteristics.

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When Statins Are Not an Option

Lowering Cholesterol Levels in Patients with Immune-Mediated Necrotizing Myopathy

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Autoantibodies Offer Clues to Co-Incidence of Cancer and Scleroderma in Some Patients

The Johns Hopkins Scleroderma Center followed a group of 168 patients with anti-RNA Pol III antibodies for five years, comparing those with and without detectable cancer.

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Rapid Response to Immune-Related Adverse Events Improves Patient Care

Published results of a Johns Hopkins pilot study showed 73.5% of physicians in the study said recommendations from an immune-related toxicity (IR-tox) team changed their diagnosis or management of immune-related adverse events.

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Favorable Five-Year Survival Reported For Patients With Advanced Cancer Treated With The Immunotherapy Drug Nivolumab

Favorable five-year survival rates from the first multidose clinical trial of the immunotherapy drug nivolumab (anti-PD-1) reported.

Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease During Antibiotic Treatment Reveals Changing <em>Borrelia Burgdorferi</em> Genotypes

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Molecular Testing of Serial Blood Specimens from Patients with Early Lyme Disease During Antibiotic Treatment Reveals Changing Borrelia Burgdorferi Genotypes

Johns Hopkins pilot study showed a direct molecular Lyme disease diagnostic test could be used to identify and genotype Borrelia burgdorferi during antibiotic treatment in early Lyme disease patients.

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Turning Silenced Cancer Genes Back Into Fighters

Targeting protein known as UHRF1 may shrink tumors by restoring aberrant gene regulation in cancer cells.

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Study Shows Experimental Drug Can Encourage Bone Growth in Children with Dwarfism

New study results provide hope for altering bone growth in children and teens with a common form of dwarfism

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Out of Many Ovarian Precancerous Lesions, One Becomes Cancer

Some deadly ovarian cancers arise from lesions genetically unrelated to each other

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Precision Medicine Symposium Highlights a New Path for Data-Driven Research

A May 30 event will spotlight the current and future role of precision medicine at Johns Hopkins Medicine.

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Johns Hopkins Study Suggests Consistent Fasting Blood Glucose May Be As Important As A1C

A Johns Hopkins study suggests people whose blood sugar varies widely over time may be at increased risk for serious health problems.

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Deep Machine Learning Can More Accurately Identify Erythema Migrans Rashes in Early Lyme Disease

A new study from Johns Hopkins showed a deep machine learning approach can more accurately identify erythema migrans rashes in early Lyme disease. This could facilitate earlier and more accurate diagnoses, earlier and more effective treatments, ...

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Unraveling Causes and Finding Treatments for COPD

News and Publications January 14, 2019

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Big Data Helps Shape A New Model for Live Kidney Donation

A tool developed by Morgan Grams, MD, PhD, screens potential kidney donor candidates by estimating their own chance of developing kidney disease, and it has been widely adopted by renal specialists around the globe.

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Optimizing Outcomes for Type 2 Diabetes with Research and Education

News & Publications January 9, 2019

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PET Imaging of Glial Activation in Patients with Post Treatment Lyme Disease

This study uses a neuroimaging radiotracer with positron emission tomography (PET) to quantify cerebral glial activation in brains of patients with post-treatment Lyme disease. Results show elevated central nervous system immune activation ...

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For Type 1 Diabetes: The End of Insulin?

News Release December 19, 2018

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Cancer Patients Blindsided by Treatment-Induced Inflammatory Arthritis

News Release December 13, 2018

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Johns Hopkins Researchers Advance Role of Circulating Tumor DNA to Detect Early Melanoma Growth, Uncover Treatment Options

News & Publications November 26, 2018

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Preventing Neonatal Infection: Researchers Improve Long-Term Outcomes for Preemies

Infection prevention efforts are paramount in hospitals, especially in neonatal intensive care units.

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Starting Early to Save Lives Later

November 2018

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New Directions in Preventing Neonatal Dysbiosis

Necrotizing enterocolitis is one of the leading causes of death in infants.

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Spread of Deadly Eye Cancer Halted in Cells and Animals

News and Publications November 12, 2018

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Hopkins Model for Glucose Management Reduces Complications, Improves Patient Outcomes

An observation that cardiac surgery patients at The Johns Hopkins Hospital who had diabetes appeared to have longer lengths of stay launched the Inpatient Diabetes Management Service.

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Gender Differences in Psoriatic Arthritis

In a recent study, Johns Hopkins researchers and colleagues show that women patients with psoriatic arthritis have worse patient-reported outcomes.

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Improving Outcomes for Critically Ill Patients

Dale Needham and colleagues investigate a novel combination of exercise and protein supplementation for patients early during ICU treatment.

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A Multidisciplinary Team Takes On Nontuberculous Myobacterial Lung Disease

Nontuberculous mycobacteria, or NTM, is now the dominant mycobacterial disease in the U.S., although the infections are not generally thought to pass from person to person. Image shows 3D rendering of NTM.